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Exploring Depression Treatments: Ketamine and Psilocybin

Ketamine and Psilocybin: Exploring Depression Treatments

Ketamine and psilocybin are two substances that have been studied for their potential use in the treatment of depression, anxiety, and other mental health conditions. While both substances have shown promise in early research, there are some key differences between them.


What are Ketamine and Psilocybin?

Ketamine is typically administered intravenously for mental health and pain and has been shown to produce rapid and significant improvements in depression symptoms, particularly in individuals with treatment-resistant depression. It works by increasing the activity of certain neurotransmitters in the brain, particularly glutamate, which is involved in mood regulation. 

Ketamine is an anesthetic medication that has been used for many years to treat pain and induce anesthesia. Recent medical research shows that ketamine is an effective treatment for depression, anxiety, PTSD, and chronic pain. When ketamine is administered at lower levels, typical of those used for mental health and chronic pain, it can induce visuals and a sense of disassociation, often described as a dream-like or an out-of-body experience. 

Psilocybin, on the other hand, is a hallucinogenic compound found in certain species of mushrooms. It works by binding to serotonin receptors in the brain, which can alter perception and induce a sense of euphoria or altered consciousness. Psilocybin has been studied for its potential use in the treatment of depression, anxiety, and other mental health conditions, and has been shown to produce changes in mood and behavior; however, research is still on-going. 


Legality of Ketamine and Psilocybin

Ketamine’s status as a legal psychedelic” stems from its approved medical applications and that it is legally obtainable for specific medical purposes. Its legal availability under medical supervision allows clinicians to administer it in controlled settings for treating certain mental health conditions, such as depression, anxiety, and pain.

Psilocybin is classified as a Schedule 1 substance by the DEARecently, some cities and states have initiated measures to decriminalize or reduce penalties for possession or personal use, driven by research demonstrating its promising effects in mental health treatment. 

Despite these changes, at the time of this article, the only legal psilocybin clinic to conduct psychedelic therapy with psilocybin under medical supervision is in Oregon. While this might change in the future as research shows potential therapeutic benefits for conditions like depression, anxiety, and PTSD, under current laws, psilocybin remains largely illegal for most states. 

Costs of Ketamine and Psilocybin

While every ketamine clinic offers different prices for ketamine therapy, at KureIV, (Updated 1/2024) the price for our ketamine infusions range from $342-380. Our recommended treatment induction plan for IV Ketamine Therapy is 6 sessions over 3-4 weeks, which is priced at $2052. Individual sessions are $380. 

Currently the costs of medically monitored Psilocybin range from $500-3500 per session, depending on the amount of psilocybin used in the experience. On top of the therapy itself, since legal clinics are only located currently in Oregon, therefore the cost of travel and lodging must be factored in. 


Length of Ketamine and Psilocybin Experiences

The duration of ketamine infusion drip and experience typically spans 45 minutes with the entire appointment, including infusion prep and recovery, lasting around 90 minutes. 

Psilocybin experiences vary according to a person’s tolerance in conjunction with the amount of psilocybin consumed. According to the experience times listed by a psilocybin clinic, they are anywhere from 1 to 6 hours long. 

Another advantage of IV ketamine over psilocybin is that if an unpleasant side effect or experience occurs during your ketamine infusion, our medical staff is able to slow down or stop the infusion till you are ready to proceed. Unfortunately with psilocybin if you are experiencing any negative side effects or emotions, you are unable to stop the experience, it ends when the psilocybin has worn off, which can be hours. 


In summary, both ketamine and psilocybin exhibit promise in treating depression and mental health conditions. Ketamine offers rapid relief in depression, anxiety, and pain symptoms, supported by scientific studies. Moreover, ketamine holds advantages in terms of cost and accessibility, being legal across all 50 states, unlike psilocybin, which is more costly and currently only accessible in a limited market.


At KureIV, we eagerly anticipate exploring the potential mental health benefits of psilocybin in the future. However, until it becomes legally feasible in Texas, ketamine stands as the only available form of “psychedelic therapy” in our region. If you are interested in learning more about how ketamine therapy can help you please fill out the form below with you preferred contact method and we will contact you as soon as possible!

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KureIV provides safe, monitored ketamine infusion therapy for people who suffer from major depression, bipolar disorder, severe anxiety, PTSD, OCD, and chronic pain in a friendly, professional environment.